about 2 days
Following I-10 between Los Angeles and Miami is the easiest driving route. The trip is about 2740 miles and would take 42 hours driving non-stop.
the best route will be by car if you are not keen on spending to much money but the answer is use if you take several buses
Greensboro, NC is about halfway but it can depend on the route you take
The Miami and Erie Canal was under construction in 1825 and finished in 1845. It connects Cincinnati to Toledo.
If you are talking about Richmond, VA its I-64 WEST to I-75 NORTH in Lexington then I-75 NORTH to Cincinnati. If you are talking about Richmond, KY, it's I-75 all the way up. If you are talking about Richmond, IN, you can take US-27 SOUTH to Cincinnati.
About 12 hours, depending on the route you take.
MapQuest estimates the driving time as 17 hours and 41 minutes.
Shortest route 9 hours 7 mins. Longest route 10 hours 8 mins.
Between 2731 and 2835 miles (depending on the route you take).
The preferred automobile route would probably take you via Indianapolis and Cincinnati.
That would depend on what route you intend to take.