What is the distance From Medford OR to San Francisco CAo?

Answer 1

362 miles taking this route:

1. Take I-5 SOUTH, from Medford, to I-505 SOUTH to San Francisco off EXIT 553 in California.
2. Take I-505 SOUTH to I-80 WEST to SAN FRANCISCO at EXIT 1A.
3. Take I-80 WEST to San Francisco.