What is the distance from Tampa FL to Lancaster SC?

Answer 1

600 miles taking this route:

1. Take I-75 NORTH to I-10 to JACKSONVILLE and TALLAHASSEE at EXIT 435. Follow signs to I-10 EAST to JACKSONVILLE.
2. Take I-10 EAST to I-95 NORTH to INT'L AIRPORT and SAVANNAH via I-295 NORTH as a bypass of Jacksonville. (EXIT 356 off I-10 to get onto I-295, follow signs to I-295 NORTH; EXIT 35B off I-295 to get onto I-95 NORTH to INT'L AIRPORT and SAVANNAH.)
3. Take I-95 NORTH to I-26 WEST to COLUMBIA at EXIT 86B in South Carolina.
4. Take I-26 WEST to I-77 NORTH to CHARLOTTE at EXIT 116 in Columbia.
5. Take I-77 NORTH to SR-9 to LANCASTER and CHESTER at EXIT 63.
6. Turn right off the exit ramp onto SR-9 EAST to LANCASTER. Take SR-9 EAST to Lancaster.