maps.google.com
The halfway point between Roanoke Rapids, Virginia and Bradenton, Florida falls approximately around Columbia, South Carolina. This city is roughly halfway along the driving route between the two locations.
Take I-10 WEST to I-75 SOUTH to TAMPA at EXIT 296A.Take I-75 SOUTH to Naples.
The quickest route is I-95. It is exactly 1210.22 miles.
Take I-65 and I-75 South via Louisville, Bowling Green, Chattanooga and Atlanta for a drive estimated by Google Maps as 17 hours and 29 minutes.
If you take a car, according to maps.google.com, the quickest route will be 286 miles and take approximately 4 hours and 21 minutes to drive.
It's the quickest route, but not the only route.
By plane. If you are driving, I5 would be the quickest, most direct route.
I-55 or US-78
The quickest route in regards to the shortest number of miles driven can be found on Mapquest.
The Pacific highway route is about an hour shorter than the inland route.
The A1 motorway.