U.S. 1, if you're crazy enough!
I-95
I-95 south
I-95.
The fastest route to drive from Orlando Florida to Jacksonville Florida is on a US Interstate highway. In this case that highway is Rt. 95.
Take HIGHWAY 102 NORTH to (TRANS-CANADA) HIGHWAY 104 WEST to AMHERST and NEW BRUNSWICK at EXIT 15W.Take the TRANS-CANADA HIGHWAY on HIGHWAY 104 in Nova Scotia and on ROUTE 2 in New Brunswick to ROUTE 95 TO I-95 to WOODSTOCK and HOULTON, ME at EXIT 188.Take ROUTE 95 to I-95 SOUTH in Houlton, Maine, U.S.A. Continue straight on I-95 SOUTH to Boston.
Take HIGHWAY 102 NORTH to (TRANS-CANADA) HIGHWAY 104 WEST to AMHERST and NEW BRUNSWICK at EXIT 15W.Take the TRANS-CANADA HIGHWAY on HIGHWAY 104 in Nova Scotia and on ROUTE 2 in New Brunswick to ROUTE 95 TO I-95 to WOODSTOCK and HOULTON, ME at EXIT 188.Take ROUTE 95 to I-95 SOUTH in Houlton, Maine, U.S.A. Continue straight on I-95 SOUTH to Boston.
Take I-95 SOUTH to I-4 WEST.Take I-4 WEST to Tampa.
About 1,308 road miles on I-95 South.
I-95 south to Jacksonville I-75 south to Tampa
You should take route 1 to the florida turnpike - florida turnpike to I-95. Take I 95 the rest of the way. It's about 24 hours driving time total.
The quickest route is I-95. It is exactly 1210.22 miles.
From Solisbury Beach Massachusetts to Kittery Maine on Interstate Route 95 is 22 minutes.