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The tribe that attacked Fort Saint Louis along the coast was the Karankawa. This indigenous group, known for their hostility towards European settlers, launched assaults on the French fort established by René-Robert Cavelier, Sieur de La Salle, in the late 17th century. The attacks were motivated by the Karankawa's resistance to foreign encroachment on their territory. Ultimately, the fort was abandoned and fell into ruin due to continuous conflicts and resource challenges.

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