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The principal route between Natchez, Mississippi, and Nashville, Tennessee, historically followed the Natchez Trace, an ancient trail used by Native Americans and later by European settlers. The Trace connected the Mississippi River at Natchez to the Cumberland River at Nashville, facilitating trade and travel. This route was significant in the early 19th century for commerce and migration, serving as a key artery for those moving westward. Today, the Natchez Trace Parkway preserves much of this historic path as a scenic drive.

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