Florida.
Florida is farthest south
The question is a bit ambiguous as it depends on what you mean by "farther." If you are asking which state is farther south, Florida is farther south than Ohio. However, if you mean which state is farther from a specific point, that would depend on the location you are measuring from. Overall, Florida is generally considered farther south than Ohio.
Florida
The states due east of the state of Mississippi is Alabama, and farther east are Florida, Georgia and South Carolina.
Minnesota is both farther north & farther south
If you at a map, you will see that Florida is a very large peninsula.
minnesota is both farther north & farther south
There is no state south of FL.
Connecticut is the farther state when compared to Massachusetts. Connecticut is located to the south of Massachusetts.
South Dakota
South America is not a US State, it is a Continent in the Southern and Western Hemispheres. Thus, Wyoming is farther north than South America.