Irina Spalko put the head on the "interdimentinal being" and it asked her what she wanted as a reward and she asked for everything it knew. it started giving her all the information and she became overwhelmed her; though it seems that the interdimentinal being knew her evil intentions because it gave her a murderous look, and thus intentionally killed her.
1939. No Mutt. No Marion. And NO Irina Spalko.
Irina Spalko, Colonel Dovchenko, Mac, Mutt (Henry) Jones
Cate Blanchett
The crystal skull entity grants her the desire to know everything, overloading her mind and causing her to disintegrate.
Irina Spasky does die in 39 Clues #6, In Too Deep.
Irina Mazing died in 1994.
Irina Press died in 2004.
Irina Bugrimova died in 2001.
Irina Godunova died in 1603.
Irina Sebrova died in 1948.
Irina Svetlitsa died on December 6, 2001.
Irina Zarubina died on May 20, 1976.