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There are several bus companies that offer direct routes from Amsterdam to Brussels, such as FlixBus, Eurolines, and BlaBlaBus. These buses typically depart from Amsterdam Sloterdijk or Amsterdam Schiphol Airport and arrive at Brussels North Station or Brussels South Station. The journey takes around 3-4 hours, depending on traffic and the specific route. It is recommended to book tickets in advance to secure a seat and potentially save money.

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