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Taking drugs by inhalation causes a very rapid increase in the level of drug in the brain. Inhaled drugs are absorbed into the arterial bloodstream in the lungs and then pumped to all parts of the body including the brain. Taking drugs by intravenous (IV) injection also causes a rapid increase in the drug level in the brain. It is slightly slower than inhalation because the drug goes first to the right side of the heart, is then pumped to the lungs where the blood is oxygenated, then goes back to the left side of the heart, and finally to the brain and body. Absorption through the skin or mucous membranes would be even slower because the drug has a longer path to travel before being circulated throughout the body. Drug response would be the slowest after ingestion because the drug goes into the digestive tract and then must pass through the walls of the stomach and intestine to enter the blood capillaries.

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