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Sectionalism, the growing divide between the North and South over economic, social, and political issues, significantly contributed to the Civil War. The North was increasingly industrialized and favored tariffs and a more centralized federal government, while the agrarian South relied on slavery for its economy and opposed such measures. Disputes over the expansion of slavery into new territories further intensified these divisions, leading to violent confrontations like "Bleeding Kansas." Ultimately, these entrenched regional loyalties and conflicts made compromise increasingly difficult, culminating in the secession of Southern states and the outbreak of war in 1861.

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