The Spanish went from the southeast to the west coast exploring North America.
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In the 1500s, the Spanish explored Florida. Around then Ponce de Leon was searching for the fountain of youth with his crew.
The first Europeans to come to the mainland of the United States were likely the Vikings about 1000 AD. However, Hernando De Soto was the first Spanish explorer to explore part of what became the United States in 1516.
Puerto Rico became a Territory of the United States during the Spanish-American war.
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Francisco Vásquez de Coronado was the Spanish conquistador who visited the southwestern part of the United States between 1540 and 1542. He did this in the hopes of conquering the mythical Seven Cities of Gold.