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The exploration of the Southeast United States was significantly impacted by figures such as Hernando de Soto, who led an expedition through the region in the 1530s, searching for gold and other riches. Other notable explorers include William Bartram, an early American naturalist who documented the flora and fauna of the area in the 18th century, and Meriwether Lewis and William Clark, who explored portions of the Southeast during their famous expedition in the early 1800s. These explorations contributed to the understanding and mapping of this diverse and culturally rich region.

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