It is an area of industrial decline, In the fields of steel making and other industrial fields.
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Indiana
The Midwest is called “America's Breadbasket” because Midwestern farmers grow a lot of the wheat we use to make bread. Why do we call the Midwest “America's Heartland?” Geography – The Midwest lies at the heart, or center, of the United States.
The Louisiana Territory, which comprised much of the central and midwestern United States, from Louisiana in the south up to the dakotas in the north.
The War Between the States was also called the Civil War.
Border states or Buffer states.