I guess you're talking about the optical drive. I guess it wouldn't. Purely because the PS4 is programmed to have it in.
If a program's executable file or setup / install files are not saved to the harddrive, no, the program will not run without the disk in the disk drive.
On compatible computers a program cannot run directly from the hard disk drive without loading it into the memory because the processor can access and address only the main memory.
If you are attempting to run a program like a game without the disk, then it is just telling you that it needs the .exe trigger on the disk. This way the program will run. However, if the disk is in and you get the same message, then your computer's disk drive is not reading the data on the disk and should be replaced. I don't recommend that you do this yourself unless you have studied computer sciences.
No, in fact there are people out there that run their computers without a removable disk drive. You only need one if you are planning to use it for a specific purpose (to run certain software that only comes on CD/DVDs).
There are certain Crack progams you can get to enable that affect but one of the simpliest ways would be to download of steam or gamefly.
Open Disk Drive. Insert Disk. Run installation. PLAY. Your Welcome.
Run DISKMGMT.MSCDISKMGMT.MSC: opens disk management utilityCLEANMGR: opens disk drive clean up utility
You can run programs from an hard drive, as long as it is plugged into a computer.
Simple... you need the installation disk. Insert the disk into the drive, and it should auto-run
You can make a CD image of each disk, then mount them into a virtual drive (like Daemon Tools) to run them.
Yes it is possible... If the laptop has a usb drive you could copy all of the files on to a usb and then run it of of that. or If the computer has a external disk/cd drive (it probably does) then you could attach a external disk drive and play it from there.
It is perfectly safe as it will use your internal memory (HDD) to emulate a Disk Drive(s) in order to run the CD(DVD)-image file from your hard drive.