How do you unpatch Fallout New Vegas glitches?

Answer 1

you can't...there would have to be a patch that fixes the bug and you won't be seeing one soon. The cause of corrupt save files are glitched areas and quests like vault 3 and fly me over the moon. The best thing to do while playing is to make pre-saves before you start a quest chain. You will have to reload with a previous save and avoid the area/quest to avoid save corruption. If you did a glitched quest early game and saved on all files that you may have to start a new game (happened to me)

Answer 2

The only way that you can really undo certain glitches is if you have the game for PC and you use the console commands. If you have the game for a console or it is something that console commands can't fix, then there is not much that you can do other then just put up with the glitch.