0
Soft Gelatin tablets usually packed in HDPE container, but now a days Blister packs are preferred due to cost effectiveness. Blister packs are of materials comprises of PVC based films and Aluminum foil as lidding material.
Plastic materials are not 100% barrier towards water vapor. Some permeation is always there with respect to permeability properties of film material and also the available area for permeation and the thickness of film.
Gelatin is a highly hygroscopic material and absorbs moisture rapidly. If the blister film get thinned down due to stretching at the time of thermoforming, it will not provide required barrier for moisture, and thus moisture ingression takes place, which is the subsequently absorbed by the soft gelatin shell.
As more moisture absorbed by the gelatin, it softens and start melting. The drug formulation ( usually a liquid) leaks out. That is why pharma companies recommend stoaring of the blister packs in cool and dry atmosphere, as the %RH and temperature directly affects the moisture permeation through blister film.
Samir Bagalkote
Pune.
What else can I help you with?
Why soft gelatin capsule leak when they containing Potassium iodide?
because the potassium eats away at stuff just like a hyena
Why can a pencil stay in a time capsule?
It does not leak ink in all the seasons the time capsule has to endure.
What would happen to net filtration pressure at the glomerulus if proteins began to leak from the glomerular capillaries into Bowmans capsule?
Are you in C34?
Is there a way to fix a PVC pipe leaking in my home?
Yes, you can fix a leaking PVC pipe in your home by first identifying the source of the leak, then turning off the water supply, drying the area around the leak, and applying a PVC pipe repair kit or using PVC cement to seal the leak.
Can a water leak cause a well to dry?
Yes, a water leak can contribute to a well drying up, especially if the leak significantly reduces the water table or the aquifer feeding the well. If water is being diverted or lost from the surrounding area due to the leak, it can lower the overall water availability. Additionally, if the leak is substantial, it may create a situation where the water is not replenished at the same rate it is being extracted, leading to a depletion of the well's water supply.
What happens when you pop a blister burn?
You should never pop a burn blister as it is the body's bandaid, but if that occurs use anti-bacterial oitment/cream and wrap it in bandage to prevent infection. When the wound is open, the fluids inside will leak out (which were protecting the newly forming skin beneath) and the burn beneath will be prone to infection. Make sure you get it covered as soon as possible and avoid infection.
When someone opens classified information on the NIPRNET this is an example of a?
Opening up classified information is a "leak" of information.
Why are my tubeless tires leaking air?
Tubeless tires can leak air due to issues such as punctures, improper installation, valve stem damage, or sealant drying out. Regular maintenance and inspection can help identify and address the cause of the air leakage.
What is wrong with a gas dryer if you smell lighter fluid during drying?
If you are smelling lighter fluid during drying, it is possible that there is a leak in the gas line connecting to the dryer. This is a serious safety hazard, and you should immediately turn off the gas supply to the dryer and contact a professional technician to inspect and repair the issue before using the dryer again.
What is the antotonym of leak?
The antonym of leak is leakproof.
How do you say leak in French?
The verb "To leak" is "Fuir". A leak is "Une fuite".
Is leak a noun?
The word 'leak' is both a noun (leak, leaks) and a verb (leak, leaks, leaking, leaked).Examples:We need to fix the leak in the roof. (noun)There was a crack in the jar that allowed the contents to leak in the cupboard. (verb)
