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Sure, it's possible, but ultimately pointless. The .22 LR is a much shorter projectile than a 5.56 or .223 projectile, and if you tried running such a cartridge through a 5.56 or .223 chamber, you wouldn't get proper headspacing from it. The end result would most likely be a catastrophic failure of the weapon which could injure or kill the firer or others.

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13y ago

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