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We can't really answer that until we know WHICH 45 and which 50. In the case of a muzzleloading black powder rifle, the .50 with have more energy, all other things being equal. However, it could also compare a 50 muzzleloader to a .45-70 cartridge rifle, which is more powerful. Caliber alone only tells us the width of the bullet.

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13y ago

What else can I help you with?