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In my experience, this would not work because guinea pigs are very determined. The male will actually manage to impregnate the female through the wire when she is in heat. You would need at least two inches of space between the cages. The good news is, if there are any small animal vets in your area, you can have your male altered (neutered, desexed), they handle the minor surgery very well and with only about the same number of complications as affect rabbits or cats.

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Q: Is it ok to put a male and a female guinea pig together in a big cage but with a metal wire in between the cage to prevent unwanted babies?
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