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You could try, but it would be difficult and very dangerous for the female. I'm not entirely sure the male would be able to copulate, actually, as the female is so much smaller than the male - it might take artificial insemination to breed the female.

Also, you run a very large risk of maternal-fetal mismatch, in which the puppies are too big to be delivered through the birth canal. If a puppy gets stuck during delivery, both the mom as well as all unborn puppies can die.

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