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A four chambered heart is a closed system and ensures that all blood passing through it is oxygenated. A three chambered heart has both oxygenated an non-oxygenated blood mixed in the single ventricle therefore the blood is at best only half oxygenated. A three chambered creature would suffer from exhaustion long before a four chambered creature.

However, it should be noted that there's a reason why frogs have a three-chambered heart. Though they breathe air using their lungs on land, they breathe through their skin using capillaries near their skin under water. When breathing through their lungs, ideally the blood entering the lungs should have CO2, so that it can be diffused out and O2 can be diffused in. When breathing through their skin, ideally the blood in the body has some CO2 so that it can be released through the skin, and O2 can be absorbed. In order to enable the frog to have CO2 in the blood in both the capillaries and lungs, it mixes the blood so that whether it's breathing through its lungs or its skin, it can manage either method passably. Although it is not specialized in breathing either on land or underwater, it is adapted to accomplish both passably, which is part of what makes it amphibian.

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