I get no credit because this is straight from Wikipedia: "Flippases (rarely, flipases) are enzymes located in the membrane responsible for aiding the movement of phospholipid molecules between the two leaflets that compose a cell's membrane (transverse diffusion)."
The phenomenon of multidrug resistance is correlated with the presence of a membrane protein, P-glycoprotein, which pumps a wide variety of drugs out of cells thus reducing their toxicity. This is similar to "flippase" but the mode of action is unknown. It requires energy as do all enzymes and is not a passive transport mechanism.
The cell membrane is a lipid bilayer, composed of phopholipids: A glyerol molecule with two fatty-acid groups at one end and a phosphate group at the other.Phospholipids are synthesised in the cytoplasm next to the endoplasmic reticulum. The ER sythesthies the lipids, and contains enzymes that catalyse the production of phopholipids such as Glycerol-3-phosphate acyltransferase. The phospholipids produced migrate naturally to the internal face of the membrane, and flippase moves them to the outer face.