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a PVRV vaccine is a rabies vaccination

(Purified Vero cell Rabies Vaccine)
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12y ago

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What is nervous tissue vaccine?

The nerve tissue vaccines are no longer available due to poor efficacy and life threatening adverse effect of neuroparalytic reactions. The currently available vaccines are the modern tissue culture vaccines (MTCV) and include Purified Chick Embryo Cell (PCEC) vaccine, Human Diploid Cell Vaccine (HDCV), Purified Vero Cell Vaccine (PVRV), Purified Duck Embryo Vaccine (PDEV). The vaccines are available in lyophilized form with sterile water as diluent, are stable for 3 years at 2 to 8°C and should be used within 6 hours of reconstitution. All tissue culture vaccines have almost equal efficacy and any one of these can be used. These vaccines induce protective antibodies in more than 99% of vaccinees following pre/ post exposure prophylaxis. The main adverse effects are local pain, swelling and redness and less commonly fever, headache, dizziness and gastrointestinal side effects. Systemic hypersensitivity reactions in vaccinees have been reported with HDCV particularly following booster injections but not with PCEC/ PVRV. Intradermal vaccination may cause more local irritation as compared to the intramuscular route. Along with proper wound care and rabies immunoglobulin (RIG) post exposure prophylaxis is effective in preventing 100% of rabies cases. Failures occur due to delay in initiation or non use of RIG when indicated.


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