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In order for a population to maintain Hardy-Weinberg Equilibrium four conditions must be met. First, there must be random mating. This means that individuals do not choose their mate based on any sort of characteristic and reproduce by random chance alone. Second, there must be no mutation or migration. This means both that there can be no mutations in the DNA of the organisms and also that individuals must not enter or leave the population. Third, the population must be large. A small population will experience genetic drift and negate the equilibrium. Fourth, there must be no selection. This means that no trait should give a survival advantage or disadvantage to the individuals possessing it.

Since it is incredibly unlikely that all of these conditions will be met, we do not see cases of Hardy-Weinberg Equilibrium in real life.

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