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Spherocytosis is often observed in fetal red blood cells (RBCs) due to their unique membrane composition and the high turnover rate in the developing fetus. The immature nature of fetal RBCs makes them more prone to membrane instability, leading to the formation of spherical shapes instead of the typical biconcave disks. Additionally, underlying conditions such as hereditary spherocytosis or maternal factors can exacerbate this presentation. This abnormal shape can lead to increased hemolysis and anemia in the fetus or neonate.

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1mo ago

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