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Usually NO!!! Older ammo used black powder (gunpowder) which is a lot less powerful than modern powder which is nitrocellulose (gun cotton) and is nothing like gunpowder. The older guns were not made as strong as today and you run the risk of blowing yourself up. That being said there is modern ammo that is designed for use in older style guns but you need to be careful and get advice on your gun.

Gunpowder is a mixture of a nitrate, sulphur, and carbon, usually charcoal.

Gun cotton is made by a chemical reaction twixt nitroglycerin and cellulose, usually cotton, which stabilizes the nitro and makes it safe and easy to use.

Strangely, the opposite is true for the brass ammo cases of many old rifle rounds. They were made very strong and can be reloaded to very high pressures as in modern guns. I have a TC Contender single shot handgun that fires a custom made round, a Schafer 360 magnum, that uses the old 444 Marlin case (from the old lever action rifle) necked down for a 30 caliber bullet and loaded VERY hot. It has more power than a modern 30-06.

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Q: Can you fire modern ammo in a pistol made in 1890?
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