What is the effect of mixing Fluoxetine with LSD?

Answer 1

Alcohol strengthens the effect of all other medications and drugs used. You can become very depressed, very unhappy and you can feel terrible if you use this combination.

Mixing alcohol with other drugs/medication is dangerous. If you still doubt, ask your doctor about it, or read the package carefully.

Answer 2

Depends on the type of antidepressant one is on. From what I have heard it's generally considered a bad idea to mix the two. Here is more specific info:

SEROTONIN-SELECTIVE ANTIDEPRESSANTS:

*Fluoxetine* (Prozac) -- even at doses of this antidepressant ranging from 2mg/day to 40 mg/day, there was an overall decrease in most effects from LSD (no matter how much acid people took), as well as a decrease in response to ketamine. There was no change in response to psilocybin. There does seem to be a decrease in the response to MDMA.

*Sertraline* (Zoloft) -- the effect with this antidepressant seems to be dose-dependent. At 50 mg/day, there was no effect on the response to LSD nor to psilocybin. However, at 100 mg/day, there was a decrease in response to both LSD and MDMA.

*Paroxetine* (Paxil) -- decrease in response to LSD.

*Trazodone* (Desyrel) -- decrease in response to LSD.

TRICYCLIC ANTIDEPRESSANTS:

*Imipramine* (Tofranil) -- increase in response to LSD.

*Desipramine* (Norpramine) -- increase in response to LSD.

*Clomipramine* (Anafranil) -- increase in response to LSD.

LITHIUM:

(*alone* or *in combination with a tricyclic antidepressant*) -- increase in response to LSD or psilocybin.

MONOAMINE OXIDASE INHIBITOR:

*Phenelzine* (Nardil) -- decrease in response to LSD

**TAKE NOTE OF THE RESPONSE TO MDMA: combining an MAO inhibitor plus MDMA has led to a hypertensive crisis and a near-fatal response in many people!!! This could be anticipated because MDMA is a substituted amphetamine, and stimulants should not be combined with an MAO inhibitor!!! DO NOT TRY THIS AT HOME!!!

Answer 3

You could fry your brain from overheating, Heart attack, Seizure. There is a reason why the bottle says do not mix with other drugs. It is just not a good idea for two reasons. If you are taking anti-depressants like zoloft because you have tremors, panic attacks, depression... and don't function well without them, why would you try to hallucinate? If you were even startled by your cat jumping in front of you mid trip, you heart would pump fast while trying to slow down at the same time because of the zoloft and you could do yourself in watching the giant mutant cat! "Meow" No really though stay off the antidepressants before you shroom. Im not gonna say you will die but its likely you could. Both of these drugs bind to serotonin receptors in the brain. Im all down for experiences and im not gonna tell you i havent done things like this but prescription drugs are powerfull and shrooms are safe alone but i wouldn't trust taking a physical downer and a super mental upper. Trip shrooms first. If you like em then you can contemplate the combo.

Answer 4

MAO-Inhibitors (antidepressants) are known to end an LSD Trip. If a person is depressed, they should not take LSD as it is known to amplify any depression one is feeling.

EX. If you have social anxiety you could feel as though you are reading peoples minds, and would fill it with bad thoughts.

Answer 5

Increased interaction to LSD - possible serotonin syndrome due to high levels of serotonin being released from the 5-HT1A and 5-HT2B receptors