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What are the effects on mitosis in a cell that has been treated with colchicine?
Wiki User
∙ 8y ago
Colcichine inhibits the formation of spindle fibres during early metaphase.Thus the cell division process stops during late prophase.micotubule has 2 ends.+ end or - end.in microtubule growth addition of tubulins(subunit of microtubule) is much faster than removal of it at - end.but if we supply cochicine to the cells,new tubulins will form complexes with colchicine and when these tubulins added to + end,further elongation is inhibited,but removal of tubulins at the other end is still continuing,so we speak about degradation of mcrotubule.the end result is division process stopped,because now,metaphase is not possible.
Wiki User
∙ 15y ago
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What is the natural source of colchicine?
According the the Centers for Disease Control, "Colchicine, a naturally occurring alkaloid derivative of the autumn crocus Colchicum autumnale and the glory lily Gloriosa superba, has been used to treat gout for centuries." -- http://www.cdc.gov/mmwR/preview/mmwrhtml/mm5640a3.htmThe crocus is mentioned on numerous alternative medicine sites as well.
Are there other medications besides allupurinal and colchicine for gout?
There are quite a few different tacks that are taken in the treatment for gout. have a look at the associated link ( How To Treat Gout With Diet and Medication) to find out more about the options available.
How long in terms of hours does a person have to wait to take colcryss otherwise known as colchicine if he had eaten grapefruit?
Persons taking colchicine are advised not to consume grapefruit at all, for the duration of their treatment. The risk being that grapefruit interacts with colchicine in a way which elevates the potency of the drug, increasing serum concentration levels, potentially leading to overdosing/toxicity side-effects. The level of reaction a person experiences correlates to how much grapefruit they consume - the greater the amount of grapefruit, the bigger the reaction.Although you are thinking ahead to your next dose, it is important to point out that colchicine has a half-life (time it takes for half of it to be excreted from your system) of about 10 hours, and assuming your drug regime is twice-daily, there would still have been some colchicine in your system when you consumed the grapfruit. It is because of this that there is no "safe" time in the day to ingest grapefruit.In this instance, the safest thing is probably to wait at least four hours between consuming the grapefruit and your dose of colcincine, since by this time you should have digested most of the grapefruit. However if your dosing regime is "once daily", just move it to as late in the day as possible and gradually move it back to your usual time over the subsequent few days.
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