Try this link:
http://books.Google.com/books?id=pX95uwhr7TUC&pg=PA5&lpg=PA5&dq=LLOQ&source=bl&ots=rMTxtfu8Xx&sig=zFd7waGheS5V1gAwFsXjWLwbsYU&hl=en&ei=adbLSrTsDYX-tQPcwYmQAQ&sa=X&oi=book_result&ct=result&resnum=7#v=onepage&q=LLOQ&f=false
it gives multiple methods for determining the LLOQ