What would you like to do?
February 2006. In recent days there has been much press coverage about new claims by American, British and Belgian scientists that they have discovered the geographical source of AIDS. These researchers have apparently detected simian immunodeficiency viruses (SIVs) that are closely related to the AIDS pandemic virus, HIV-1, in the stools of wild chimpanzees living in the very south-eastern corner of Cameroon, in western Africa.<META content="OpenOffice.org 1.9.104 (Linux)" name=GENERATOR><META content=20060220;15115700 name=CREATED><META content=16010101;0 name=CHANGED><STYLE type=text/css> </STYLE>Much of this new information is important and valuable. However, much of the accompanying analysis is exaggerated, and not for the first time seems to be driven by an underlying desire on the part of the authors to bolster the bushmeat theory of origin of AIDS, which proposes that humans first got infected through the butchery and consumption of chimpanzee bushmeat. In fact, as I shall demonstrate, their claims of having established the source of HIV-1 and AIDS are far from convincing. Furthermore, their new findings are as consistent with the oral polio vaccine (OPV) theory of origin as they are with the bushmeat theory. [See note at end of this section for explanation of OPV theory.]The new information about the Cameroonian chimps was released in February 2006 at the 13th Conference on Retroviruses and Opportunistic Infections in Denver, Colorado, where important speeches were made by Brandon Keele, from the lab of microbiologist Beatrice Hahn at the University of Alabama in Birmingham (US); by Fran van Heuverswyn, from Martine Peeters' lab in Montpellier, France; and by Hahn's long-time collaborator, the geneticist Paul Sharp, who is based at the University of Nottingham, UK.In a 30-minute speech entitled "Where AIDS Came From" (which is available on a Webcast), Professor Sharp stated that the regions in Cameroon where they had found these chimpanzees were in "the south-eastern extremity" of the country, and claimed that this area represented the "likely origin of HIV-1". He noted that this region was a long way from the city of Kinshasa, in the Democratic Republic of Congo (formerly Leopoldville in the Belgian Congo), where he believes that the AIDS pandemic started. However, he then added that "there is a river that runs most of that distance", by which he meant the 500-odd miles between south-eastern Cameroon and Kinshasa.Below, I shall summarise the latest findings, and provide my analysis of their significance, before explaining why this new information still poses some real problems for advocates of the bushmeat theory. After that, I shall provide some further background about the history of research into the origins of HIV-1 and AIDS. Finally, I have posted two articles about the new chimp SIV findings that have recently appeared in the press: an instant commentary by Ed Susman of UPI, followed by a more reflective piece by Jon Cohen, for ScienceNOW.](Background note. The oral polio vaccine theory, or OPV theory, proposes that the AIDS pandemic was sparked by approximately 30 separate vaccination campaigns that were staged in the Belgian Congo and Ruanda-Urundi between 1957 and 1960, and which employed an experimental OPV called CHAT. Lindi camp, which housed several hundred captured chimpanzees, was established in the rain forest a few miles outside Stanleyville (now Kisangani), and was set up specifically in order to test, or "perfect", this CHAT vaccine. Despite denials by the vaccine-makers, there is evidence that a significant proportion of the CHAT vaccine that was tested during these years on approximately one million Africans was prepared locally in Africa, in the cells of the Lindi chimps. This means there is a high probability that different batches of the vaccine were infected with different variants of chimpanzee SIV.)The new information from Cameroon.The most significant discoveries announced by the teams of Hahn, Sharp and Peeters may be summed up as follows:
- They have obtained viral isolates of SIV, simian immunodeficiency virus, from over 30 wild-living chimpanzees (Pan troglodytes) from south-eastern Cameroon, thus tripling the number of known isolates of SIVcpz (chimpanzee SIV).
- They have sequenced these isolates, and found sequences that are genetically "much closer" to HIV-1 Group M (the virus that caused the human AIDS pandemic) than any previous sequences.
- They have discovered one group of wild chimpanzees in which 35% of the members are infected with SIV, a higher infection level than in any wild-living chimp group previously analysed.
- The great hunter-gatherers of this region of south-eastern Cameroon (like many other parts of central Africa) are the pygmies. However, early studies of HIV infection in pygmies from across the central African rain forest detected zero HIV-1 infection, followed in later years by low levels of infection, which could be traced to sexual encounters between pygmies and local Bantus, who had clearly introduced the virus. One study examined 340 sera that had been obtained between 1975 and 1978 from the Aka pygmies, living on the borders between Congo Brazzaville and Central African Republic; not one sample was HIV-positive. These Aka pygmies would appear to be from the same group as the pygmies of south-eastern Cameroon, who are commonly referred to as the Baka; they live an estimated 100 to 150 miles east of the area highlighted by Sharp. A later HIV seroprevalence study of pygmies specifically from southern Cameroon found that HIV infection was "very rare", even by the 1990s.
- In the last few years, two American military scientists (doctors Burke and Wolfe) have made an exhaustive search for SIV-like infections (rather than HIV infections) among hunter/gatherers from different parts of Cameroon, with completely negative results for the 76 plasma tested. (They found a host of other viruses, including several infections with a foamy virus which, like SIV, is a simian retrovirus. But they found no SIV.) Burke and Wolfe also tested 1,224 plasma from a general population coming from urban and rural areas of Cameroon, where people "may handle [primate bushmeat] but are unlikely to have repeated contact with the blood or body fluids of freshly killed animals". Just one of these plasma showed some indications of exposure to SIV (in this case SIV from a colobus monkey) by one of the assays used (ELISPOT), but the result was hardly convincing, for the plasma in question showed only weak cellular reactivity, and the authors were unable to amplify any SIV nucleic acids. This might have been a false positive, or it might be that they had genuinely detected one single human exposure to SIV in over 1,300 plasma, but that this exposure had failed to cause any productive human infection. Burke and Wolfe's research, which appeared to be specifically designed to obtain data that lent support to the bushmeat theory of origin, actually did the exact opposite. There is still no data that directly supports the hypothesis that hunters get infected with chimpanzee SIV through the handling and cutting up of chimpanzee bushmeat. [See separate essay about the Burke and Wolfe research, soon to be posted on this web-site.]
- Paul Sharp apparently claims [see Susman article] that in 1959 "there were probably thousands of people in the region" between Cameroon and Kinshasa who were already suffering from AIDS. This is not the first time that Paul Sharp has suggested this, but it gives some idea of the superficial nature of some of his analysis. The reality is that there is zero evidence of either early HIV-1 infection or of early AIDS in either Cameroon or Congo Brazzaville. Now let us look at Africa as a whole. Even after more than twenty years of searching for early African samples in Africa, North America and Europe, only one single sample of HIV-1 has been found that dates from before 1970. (This is ZR59, an HIV-1 sequence that was obtained from plasma sample L70, which was allegedly collected in 1959 from Leopoldville. The portion of the HIV-1 genome of ZR59 that has been sequenced is tiny, representing less than 5% of the entire virus.) Furthermore, there is no convincing report of AIDS-like disease in Africa before 1962 (a woman originating from Lisala, DRC), and no further convincing example prior to 1973 (a child born somewhere in the DRC, perhaps in Kinshasa). These findings conflict sharply with Professor Sharp's claim that "thousands" of Africans were affected with AIDS by 1959. Perhaps he believes that only Western doctors would report such unusual conditions, or record them for posterity. If so, perhaps he should bear in mind that the Belgian Congo, Cameroon and Congo Brazzaville were still staffed with Belgian and French doctors up to independence in 1960 - and in many cases after that as well.
- The part of south-eastern Cameroon highlighted by Sharp is, in reality, not very remote or isolated. There are three quite significant roads running from this area to major centres. One road runs north to Yokadouma, and then either west to the Cameroonian capital of Yaounde, or else east to Bangui, capital of the Central African Republic (CAR). A second road crosses over into Congo Brazzaville at Moloundou, and ends up either at Libreville, the capital of Gabon, or else at Yaounde in Cameroon. The third (and largest) road runs due south through Congo Brazzaville from Ouesso to the capital, Brazzaville. However, Sharp proposes that an SIV acquired by a local citizen from one of the Cameroonian chimpanzees escaped from this area by river, after which the virus got established in only one place, this being Leopoldville/Kinshasa, 450 to 500 miles away by river-boat. To make this happen, an infectee (or chain of infectees) would have needed to carry the virus southwards across two national boundaries (from what was then French Cameroon to French Equatorial Africa, AEF, and from AEF to the Belgian Congo), in an age when few Africans crossed borders, especially those separating different colonial masters. Furthermore, this infectee (or chain of infectees) must not have sparked any outbreaks of AIDS en route. This index virus would (according to Sharp's scenario) have had to have passed through Ouesso, the river-boat terminus just south of the border between Cameroon and Congo Brazzaville. In 1949 Ouesso was a major town of 26,000 people, and the second largest town in Congo Brazzaville (nowadays officially titled the Republic of Congo); it was a trading centre for mahogany, sisal, palm products, copal and rubber. If this was the route whereby early HIV-1 reached Leopoldville, then the bushmeat hunter/butcher/trader would presumably have had to have spent some time in Ouesso waiting for the steamer southwards. Yet there is no evidence of early HIV infection in Ouesso, and the first evidence of HIV-1 in Brazzaville emerges indirectly, when a Soviet man who received a blood transfusion in that city in 1981 returned to the USSR, and sparked a mini-epidemic there. But 1981 is two decades after the first evidence of HIV-1 in Leopoldville/Kinshasa.
- Early inklings of these results must have been available for some time, and it would seem that recent attempts may have been made to check the HIV-1 variants currently found in areas bordering the range of the Cameroonian chimpanzees. Research published in late 2005 about HIV-1 diversity in three rural health centres in eastern Cameroon, along the border with CAR, revealed that 27 of 40 HIV-1 viruses detected were classic subtype A, and that one was subtype F2, while the other twelve were recombinant viruses ("circulating recombinant forms", or CRFs) containing traces of subtypes B, E, G and J. The authors described this area along the Cameroon/CAR border as "a potential hotspot of HIV-1 recombination", but this was apparently because the region appeared to lie at the meeting-place of one mini-epidemic spreading westwards from CAR, and another spreading eastwards from Cameroon. However, there were no traces (even as elements of recombinant viruses) of several major subtypes, notably C and D. Moreover, it is not clear just how close any of these health centres were to the range of the chimpanzees. Further research published in early 2006 (and conducted in 2003-4) concerning five health centres in Congo Brazzaville, including Brazzaville and Ouesso, detected all the major HIV-1 subtypes, plus five of the more common CRFs. However, this survey covered the whole country - and as the pandemic progresses and affects over 40 million persons world-wide, subtypes and CRFs are becoming far more common in every country. By contrast, an article on genetic diversity in Cameroon published in 1994 reported the presence of only five subtypes in the country. The relevance of these results must be compared to the finding of all eleven of the recognised HIV-1 subtypes A to K (and some CRFs) in sera collected in 1983-6 in a single city (Kinshasa): data that is highly significant with respect to the genesis of AIDS. To sum up, there is no evidence of a wide variety of HIV-1 subtypes emanating from either south-eastern Cameroon or from Congo Brazzaville at an early stage of the AIDS pandemic.
- It becomes apparent that Hahn and Sharp still have no adequate explanation for how the AIDS epidemic that we see today could have been engendered. In fact, for their hypothesis of origin to work, they have to propose a quite extraordinarily far-fetched scenario. They have first to postulate a single chimp virus that crossed (via chimp bushmeat) to humans in south-eastern Cameroon, and which was then transported to Leopoldville/Kinshasa, where it for some reason diversified into many different subtypes at the very start of the epidemic (which, according to them, was in the 1930s and 1940s). They surmise that later on (perhaps in the 1960s or 1970s) these various subtypes began to escape from Kinshasa to establish epidemics of specific subtypes in different locations around Africa, and around the world. Later again, they postulate, various of the subtypes started to meet up again in the cells of individual human infectees, and to create recombinants, which were then passed on to others to become CRFs, circulating recombinant forms.
13 people found this useful
Was this answer useful?
Thanks for the feedback!
It won't protect you because it is the fluid that is contagious. Not the sperm or way have you.
they havent. they havent.
Definitelty, absolutely, yes. If this has happened, see a doctor immediately!
What is the hiv/aid statises in France? What is the hiv/aid statises in France?
HIV is caused by people who have had sexual contact with another infected person.
Robin got it from her ex-boyfriend Stone years ago . She had a baby with Patrick but I don't understand how he doesn't have HIV . That's my next question ... answer people ple…ase!!!
HIV (Human Immunodeficiency Virus) affects the body's immune system (white blood cells.) It uses cells associated with immune function to reproduce.
well the businesses wont be able to operate with an HIV/Aids person because he/she wont be working as 100%. he works almost 50/20%
the t cells in the body
i don't know 0.0
The circulatory system being one of the 11 organ systems in the body plays a vital role in the transfer of blood to other parts of the body. HIV, being a virus that effects th…e body, will be transferred into our blood and body. The circulatory system transfers that "dirty" blood to the rest of the body. The immune system is generally weaker when HIV is formed. Therefore, if people with HIV act upon quickly for treatment then AIDS won't be formed.
Healthy People have between 700-1500 CD4 cells,these cells are part of the Immune system and locate and coordinate the destruction of infections. HIV destroys these cells mean…ing it becomes harder for the body to locate and destroy infections,which leads to poorer health.
HIV treatments must be promptly administered to anyone diagnosed as HIV positive. These treatments slow down the course of the disease. As per WHO, HIV treatments include us…e of at least three antiretroviral drugs to suppress the HIV virus. Various classes of drugs that are helpful in HIV treatment are non-nucleoside reverse transcriptase inhibitors, protease inhibitors, integrase inhibitors, entry inhibitors, fusion inhibitors, CCR5 receptor antagonists, maturation inhibitors, etc. The drugs bevirimat and vivecon are being investigated for their benefits in HIV treatment.
the CD4(T-cell)lymphocytes is affected by HIV and aids
Yes, a nursing mother can transfer HIV through breast milk.
Resources relative to the population, e.g. food, clean water, air Threats relative to the population, e.g. presence of predators, disease, or environmental dangers Reproducti…ve effectiveness: how many offspring does each couple have, and do the offspring correctly fabricated (not too many genetic mutations) so they are survivable. Presence of another species that wants the population to survive. For example, ants sometimes keep aphids as a source of food. Perhaps more close to home, humans keep a population of cows as a food source.