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Defensive or drug resistant viruses grow by mutation. Viruses are exposed to many cellular factors during the replication of viruses, some of the factors can do actually mutate the viral genomes. Viruses take advantage of these factors to form as a genetically modified (new) virus that may not be cured by a particular drug since the virus has evolved to escape from the effect caused by the drug!

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Q: How the defensive viruses grow?
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