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Generally speaking, Prader-Willi Syndrome is not inherited. It is a random error/mutation to the 15th chromosome that occurs at conception. In around 70% of the cases, the mutation is a deletion (or microdeletion) of some of the genes on the 15th chromosome. In around 25% of the cases the error/mutation occurs because the baby gets 2 15th chromosomes from the mom instead of one from mom and one from dad, and since the genes that impact the symptoms of PWS should come from the dad if the child has 2 sets from the mom the genes are silent and therefore it is the same as though they were missing/deleted. In the rarest of cases PWS is caused by an imprinting error which can either occur randomly at conception or be passed from the father (who would not have PWS himself)....again this last kind is extremely rare.
See Sources and Related Links for the Prader-Willi Syndrome Association (USA) and more detailed information.
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