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It is working for my mother, a doctor prescribed 2 methadone 5mg pills every 8 hours and 4 .5mg xanax a day. I asked the pharmacist if there was an interaction and they said no, it could just make her a little tired or sleepy. My mom is doing good on the combination.

Always be sure all your doctors know all the medicines you take, even if some were prescribed by a different doctor, or are natural or over the counter remedies. Only your primary health care provider can tell you if this drug combination would be okay in your case. Some combinations of drugs are fine for some people, but if the drug side effects include possible kidney or liver damage, the same combination would not be good for a person who is already being monitored for signs of organ damage from another drug.

Be very careful not to increase dose if your mother is at all confused or of advanced age. Both methadone and xanax are depressants that depress the part of the brain stem that tells your brain to have your body breathe and significant apnea can occur at this high of dose of xanax. This worries me.

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13y ago
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11y ago

Yes, but you must obtain a letter from the doctor prescribing benzo's (xanax, klonopin, Ativan, etc.) stating that she/he (the dr.) is aware you are under methadone treatment AND that you are also prescribed the benzo. You must inform the prescribing dr. and have them make these 2 statements in the form of a letter for your clinic. You will also have to take your bottle of xanax in each month so they can record it. This information is for those who have a valid prescription for the benzo.

Add: You can take methadone and xanax at the same time but it is highly dangerous and not recommended by almost all physicians. The only reason you would be taking Xanax while on methadone is if you are SEVERELY depressed or suicidal. Of course there are some other circumstances, but they must outwiegh the high risk of death associated with mixing these two narcotic medications.

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11y ago

Yes, but it is strongly not recommended by most doctors. The benefits must outweigh the risk, and in this case the risk is very high. I have seen many people die from this combination of medications.

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14y ago

No. Depending on the dosage, I wouldn't advise it. Both will make you nod. You could burn your house down (or worse) if you aren't careful. . .

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11y ago

No. Its very stupid. That said I have done it and some. But I am here typing. I'm 30 y/o male with a tolerance. I would say to anyone else. NO NEVER TAKE THAT COMBINED

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11y ago

No u will die from mixing them all together I had a couple of friends that died like that so please dont

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12y ago

Yes

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Q: Can you take 10mg of methadone and 1mg of xanax 12 hours apart and be safe?
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How long can you take a xanax after stop using methadone?

Since I'm sure you read Methadone and Xanax is commonly a lethal combination, I wouldn't recommend doing this unless you have a prior high tolerance to heroin or Oxycontin AND Methadone, as well as experience with Xanax. I've taken 10mg of Methadone and 1mg of Xanax a few times and it was perfect. Then again, I had a tolerance to 80-120mg of Oxycontin, a tolerance of up to 20mg Methadone (pill form, not the liquid) and took 1mg of Xanax with it and was perfectly okay. I really don't recommend this to anyone since everybodys different, but I've known several tolerant people who have done this and have been okay. However, if you do not have tolerance to any of these medications, I would definitely take them separately. I would wait at least wait 6 hours before taking Xanax after your Methadone dose, or vice-versa if you absolutely must. Take care!


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