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That is not possible as far as changes that would be great enough to affect tests for family connections. Very rarely, some genetic changes occur during pregnancy and some can have devastating consequences. The condition known as progeria is an example of a de novo genetic mutation (it happens to the embryo). The child ages at a rate as much as ten times faster than normal. such children rarely live beyond the mid-teen's.

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Q: What are the chances of a baby's DNA changing during pregnancy?
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