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The term second messenger was given with the discovery of chemicals that work inside the cell. Hormones and other molecules that function outside the cell are called first messengers in the transmission of information.

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10y ago
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12y ago

Most subcellular processes are homeostatic, such that different types of cellular processes occur when there are higher and lower cytosolic concentrations of certain molecules. Most textbooks frame the issue in the way that certain types of membrane-bound metabotropic receptors couple with and activate g-proteins. The g-protein then couples with a substrate and either produces or metabolize second messengers like ATP or GTP.

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14y ago

Calcium Ions and Cyclic AMP are both the two big second messanger

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Q: What are the roles of second messengers in signal transduction pathways?
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