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The anti-inflammatory actions of methotrexate are critically dependent upon the production of ROS; thus, although NAC therapy has been suggested for rheumatoid arthritis, it should not be prescribed to patients taking methotrexate This material is sourced from the following article( N-acetylcysteine - passe-partout or much ado about nothing?) and can be seen by following the related link below.

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Q: What are the sideffects of N-acetylcsyteine on patient taking methotrexate?
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Does taking methotrexate disqualify you from donating blood?

Yes. You cannot donate blood while on methotrexate.


Is alcohol absolutely contraindicated when taking methotrexate?

Yes. Your liver does not need to process alcohol while you are on methotrexate.


Should you take vitamins when taking methotrexate?

vitamin c


Can taking ibuprofen with methotrexate cause bloodshot in eyes?

yes


Can you take statin when taking methotrexate?

Methotrexate when taking with atorvastatin (Lipitor), pravastatin (Pravachol), and simvastatin (Zocor), can cause serious liver problems. It's best to consult with a physician or pharmacist before taking these two together.


Can you take anitbiotics taking Methotrexate?

Yes, you can. You will actually be more likely to get infections, and get them worse, when on methotrexate. At some point, you will likely need antibiotics.


Can you fly abroad while taking methotrexate?

Yes. The prescription bottle for methotrexate must have your name on it, as well as the proper information (as printed from the pharmacy).


Can you pierce ears when you are taking methotrexate?

Yes, just be very careful to keep everything quite clean. You are more susceptible to infections while using methotrexate.


Can you take Ativan and methotrexate at the same time?

There have been reports of people taking Atvian and methotrexate together at the same time. However taking both of these drugs together can increase the risk of side effects such as dizziness and drowsiness.


What are the side effects of methotrexate and penicillamine?

may cause birth defects. Women taking these drugs must stop taking them during pregnancy and for several months before a planned pregnancy. Methotrexate may also cause lung damage or fertility problems


Can you drink alcohol while taking methotrexate?

It is largely unadvisable to consume alcohol whilst taking leflunomide (or its sister drug, teriflunomide). There is a known risk of liver damage in patients taking leflunomide and alcohol increases the risk of this occurring.


Can you take methotrexate with a cold?

Yes, you should continue to take methotrexate unless your doctor advises you to stop.