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Mutations in the alpha-L-iduronidase (IDUA) gene located on chromosome 4 cause the MPS I disorders (Hurler, Hurler-Scheie, and Scheie syndromes
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What are the mucopolysaccharidoses disorders caused by?
The MPS disorders are caused by absent or insufficient production of proteins known as lysosomal enzymes The specific enzyme that is deficient or absent distinguishes one type of MPS from another
What does the treatment of MPS disorders consist of?
Treatment of the MPS disorders primarily consists of supportive care and management of complications. Bone marrow transplant (BMT) and enzyme replacement are two promising therapies that offer the possibility of altering the course of these conditions
What are the causes of MPS?
Each type of MPS is caused by a deficiency of one of the enzymes involved in breaking down GAGs.
What causes MPS IV B?
MPS IV B is considered the milder form of the condition. The enzyme, beta-galactosidase, is deficient in MPS IV B. The gene involved with MPS IV B (GLB1) is located on chromosome 3.
What are common heart problems of patients with MPS disorders?
Common problems include abnormal heart valves, narrowing of the blood vessels in the heart, and weak heart muscles (cardiomyopathy). Patients with MPS I H and the severe form of MPS II usually have damage to the mitral valve
What causes MPS II?
Mutations in the iduronate-2-sulphatase (IDS) gene cause both forms of MPS II (mild and severe). Nearly all individuals with Hunter syndrome are male, because the gene that causes the condition is located on the X chromosome.
What are the causes of genetic human disorders?
The causes of genetic disorders areThey can be inherited through Parents;Mutations may occur;A deletion may occur.These are the causes of a genetic disorder.
What causes a person to form an eating disorders?
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What are the 7 types of mucopolysaccharidoses?
Hurler (MPS I H), Hurler-Scheie (MPS I H/S), Scheie (MPS I S), Hunter (MPS II), Sanfilippo (MPS III), Morquio (MPS IV), Maroteaux-Lamy (MPS VI),
What causes disorders such as infantilism?
Infantilism, which is a paraphilic infantilism disorder, is believed to have psychological origins, such as unresolved emotional issues from childhood or traumatic experiences. It is often considered a way of coping or escaping from adult responsibilities and stressors. Therapy and counseling can help individuals understand and address the underlying causes of this disorder.
Which MPS are inherited in an autosomal recessive manner?
MPS I, MPS III, MPS IV, MPS VI, MPS VII, and MPS IX are inherited in an autosomal recessive manner which means that affected individuals have two altered or non-functioning genes,
What are the causes of impulse control disorders?
The exact causes of impulse control disorders are not fully understood as of 2004. Individuals who have had serious head injuries, however, can be at a higher risk for developing impulse control disorders, as are those with epilepsy.
