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An positive ANA (antinuclear antibody) means that you make antibodies that attack the circulating debris of the nucleii of your own cells that have died. A titer of 320 means that your blood had to be diluted320 times before they got a sample that had no antinuclear antibody. Typically the numbers are 40, 80, 160, 320, 640, and so on. Lupus presents a speckled pattern, not a nucleolar pattern.

10 million Americans have a positive ANA. Only 1.5 million have lupus. Many people have a positive ANA and no active disease of any kind. Unless you are having some kind of symptoms, don't be overly concerned.

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12y ago
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Anonymous

Lvl 1
3y ago
You didn't answer the nucleolar pattern part, which is key. It differentiates diseases like lupus from scleroderma and CRST syndrome. 

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Q: What does a High ANA of 1 to 320 with a nucleolar pattern mean for my health?
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