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I think the most recommended immunizations that I saw were for typhoid and hepatitis A (which are the shots I got before I went). If you go to your local health department, they should have information on what immunization are necessary. They also have the option of giving you pills for prevention of malaria, but I wouldn't bother with those. Just make sure to bring bug spray in case you decide to go into any areas filled with foliage. From my experience there, as long as you make sure to drink bottles water and eat foods that have been cooked at high temperatures you should be fine. Plus, Antigua is a very "touristy" place, and is pretty clean.

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Q: What immunizations are needed for antigua Guatemala?
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