Ineffective Erythropoiesis as described by Goljan's Rapid Review in Pathology:
RBC's with alpha-chain inclusions undergo apoptosis in the bone marrow. You can see why the term is as such because RBCs are damaged/apoptosed/removed prior to release, resulting in 'ineffective' erythropoiesis.
Ineffective erythropoiesis is the active erythropoiesis with premature death of created red blood cells RBCs, a decreased output of red blood cells from the bone marrow and consequently anemia.
Heat makes it ineffective
Erythropoiesis is the process by which red blood cells (erythrocytes) are produced. In human adults, this usually occurs within the bone marrow. In humans with certain diseases and in some animals, erythropoeiesis also occurs outside the bone marrow, within the spleen or liver. This is termed extramedullary erythropoiesis.
erythropoiesis bone marrow
Red blood cells are formed in the bone marrow.
Occlusion that leads to blood supply
thalassemia
Hypoxia in the blood triggers erythropoiesis.
Erythropoiesis requires B12, Folic acid and iron.
No
vitamin K
Anemia
There are three main events that are considered stimuli for erythropoiesis. These are aerobic exercises, living in an environment with a high altitude, and hemorrhages.
Sanford B. Krantz has written: 'Erythropoietin and the regulation of Erythropoiesis' -- subject(s): Erythropoiesis, Erythropoietin
Erythropoiesis (production of red blood cells) will occur when there are not enough red blood cells (RBCs) in circulation. Therefore the stimulation for erythropoiesis to occur is too few RBCs in the blood, which can be termed 'anaemia'.
erythropoiesis
Erythropoiesis.
erythropoietin