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Receptor internalization is the process by which cell surface expressed receptors are monoubiquitinated following ligand-induced activation, and subsequently taken up into the endocytic vesicles to the lysosome. The receptor will either be degraded or brought back to cell membrane were it is again able to interact with its ligands. Receptor internalization serves as a mechanism to downregulate receptor signaling upon agonistic ligand stimulation.
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What has the author M Payne written?
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