Please rephrase your question so that we know what event on or near the Euphrates you mean. The river Euphrates has been there from long before the dawn of civilization until the present day.
Mesopotamia has two rivers, the Tigris and the Euphrates.
The Tigris, the Euphrates, the Diyala and the Khasa are the main ones.
No empire based in Egypt ever controlled the Euphrates River, but the Ayyubid Empire, which was based in Egypt came the closest to doing so in the mid-1100s.
Euphrates.
The Tigris and Euphrates Rivers flow into the Persian Gulf.
The Tigris and Euphrates rivers
The Euphrates is in Iraq.
Those two rivers are the Euphrates and Tigris.
The Euphrates River
Mesopotamia has the Euphrates and Tigris Rivers.
The Euphrates river ends in Iraq
Euphrates College was created in 1878.