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Mayor James Duane (1733-1797), a member of the Continental Congress who was appointed the first post-British Mayor of New york (by Governor George Clinton) in 1784. A highly respected lawyer, Duane was a key drafter of the NYS Constitution and a signatory of the Articles of the Confederacy. He opposed the Declaration of Independence, but support the American cause in the war that followed.
Duane, a scion of New York's Anglo-Dutch elite, lived at Gramercy Farm in Manhattan, which his son (also named James) later sold for development as the Gramercy Park neighborhood, and owned an estate west of Schenectady in and around the current town of Duanesburg, NY.
Duane's grandson, Brigadier General James Chatham Duane (1824-1897) also achieved prominence as Chief Engineer of the Army of the Potomac during the Civil War, eventually becoming Chief of the Army Corp of Engineers and Commissioner of the Croton Reservoir.
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Was there another Duane Reade apart from the drugstore?
The popular drug store originally was located in between Duane Street and Reade Street on Broadway. It took its name from from the bordering streets. The location still exists today. If you wander around New York City's downtown area, you'll come to a section on Broadway, not far from City Hall, edged by two streets: The streets are Duane Street, and Reade Street. Duane and Reade Street do not intersect, they are parallel. In answer to your question, the original Duane Reade pharmacy was located there. The store isn't named after a real person. The original Duane Reade was one of three drugstores in downtown Manhattan opened by the Cohen Brothers in 1959. They called their stores "Thrift" originally, but, with so many thrift shops around, that was confusing. Their main store was on Broadway between Duane and Reade, and the Cohens noticed many of their workers (mostly immigrants who had great trouble pronouncing "thrift") refer to the main store as "The Duane and Reade shop." The name stuck. James Duane was mayor of New York City from (February 6, 1733
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