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Why do penicillin have a better therapeutic index than other antimicrobial?
Wiki User
∙ 10y ago
Yes these are the antibiotics which have the highest therapeutic index.. That too penicillin is exceptionally high... The only side effect which is considered significant from these two groups of antibiotics is Hypersensitivity reaction or allergis reaction which can be lethal also in some of them..
The reason is, both of these belong to a group of beta lactum antibiotics and they both have a protein structure and they are easily metabolised in the body.. If they ast on bacteria than they are antibiotics otherwise they are mere protein food, just like giving parentral nutrition... Hence they have a huge therapeutic index..
Wiki User
∙ 10y ago
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What does low therapeutic index mean?
Drugs with a low therapeutic index have a narrow margin of safety.
What is the Therapeutic Index of Tobacco?
100
What is the therapeutic index of drugs?
The therapeutic index of drugs is the ratio between the amount of drug needed to kill 50% of the cells of the experimental animals and the dose needed for 50% of the cells to respond. The larger the therapeutic index, the safer the drug.
Is therapeutic index a useful measure of safety?
It is for certain drugs such as Digoxin as they have such a narrow therapeutic index. For drugs with a wide range of therapeutic index, the best measure of safety is the maximum daily dose, its effect on the patient and what other drugs it interacts with. Ask your pharmacist for specific safety questions on your specific drugs.
What are the nursing responsibilities of digitalis?
Digitalis has a very narrow therapeutic index, therefore, the dose must be carefully be monitored for each patient.
What is better - a machinability index of 100 or 0?
100
Why is HDI better than GDP?
it is better because it measures the life expectancy index, education index and the income index and square roots it by the power of 3. it is taking in account several types of indexs and getting an average (kind of!)
Why are index fossils more useful then other fossils to paleontologist?
It is because the index fossils has better minds than the paleontologist.
How much less toxic is marijuana then other drugs?
Toxicity of any drug is described by its Therapeutic Index--the ratio of lethal dose to effective dose. For instance, if the effective dose--the dose that gets you high--of Soma (the fake one in Brave New World, not carisoprodol) is 10 ng/ul and the lethal dose is 100 ng/ul, Soma's therapeutic index is 10. Marijuana has no therapeutic index as it has no lethal dose. The only other drug I know of that can come close to saying that is LSD, whose lethal dose is 12,000 micrograms--this for a drug that's normally taken 100 micrograms at a time. (Given that, erowid reports that ONE person has died of an LSD overdose; the guy thought it was speed and injected 320mg--not micrograms but milligrams--of acid.)
Where is the therapeutic index of a drug listed?
Having worked in the pharma industry in senior positions in clinical drug development for 30 years, the therapeutic index of a drug is essentiallya qualitative concept of risk:benefit ratio for one drug vs another and is NOT a real number. There is no agreed upon formula for computing the therapeutic index of a drug using clinical results. The reason the formula does not exist is that it would require a consensus agreement among experts for each disease regarding the definition of a clinical response (patients usually show graded responses, not simply full response or no response) and a consensus definition of the clinical toxicity of a drug. For example, if a medication produces side effects consisting of dose-dependent increases in blood pressure, decreases in white blood cell counts and vomiting--what criteria shall be selected for a toxic risk? In animal studies. the ratio of LD50/ED50 (dose in a species that kills one half of the animals divided by the dose that is effective in the disease model in one half of the test animals) is sometimes computed and can be helpful in deciding which of several potential drug candidates is to be selected for development. It is probably possible to find in select publications, sufficient information to compute a therapeutic index that compares several drugs using a uniform definition of the dose needed to produce the same therapeutic benefit and the dose needed (on average) to produce a side effect of sufficient severity to qualify as a dose-limiting problem. Even in this case, the therapeutic index would be essentially an ad hoc determination produced by the author or reviewer. It would likely not be regarded by others as the therapeutic index for the drugs assessed because other experts would likely employ a different definition of side effects of concern.
What is narrow therapeutic index?
A therapeutic index refers to eiffernce between the minimum level a medication must reach within the body for it to be effective and the maximum level a drug will reach before a medication causes side effects. For most medications there is a large range between these two values. A narrow therapeutic medication has a must smaller index. Some medications for seizurers or thyroid disease (for example other medications fall into the group too) have a small difference between what dose it required to achieve a proper response and too much that might cause a side effect. All of these medications are dose based on specific patient characteristics and many require frequent blood work or other clinical monitoring. Discuss your questions/ concerns with your pharmacist or other heathcare provider.
Is the show to aru majutsu no index and aru kagaku no railgun the same or different and if they are different which one better?
They are similar. Toaru kagaku no railgun is just a spin-off of Toaru majutsu no index an is only about Mikoto Misaka (who is the Railgun and is in Toaru majutsu no index) and her three friends. Toaru majutsu no index is better, as it is the original, has two seasons and involves more characters and plots
