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DNA replication is : semiconservative, bidirectional, begins at unique sites (origins)
DNA replication
DNA replication
synthesis of DNA DNA Replication
DNA controls the formation of cells in your body, the products they release and everything they do, as well as the process of protein synthesis. DNA is found in the cells nucleus (the control center of the cell) in the chromosomes (which are composed of DNA strands). DNA is in a shape like a coiled ladder (a double helix), the sides of the "ladder" are made up of alternating subunits of sugars and phosphates and the "ladder rings" are pairs of nitrogen bases, adenine and thymine, guanine and cytosine. The sequence of these bases forms a code, which controls the production of proteins in the cell. A section of the DNA that codes for a specific protein is called a gene. The Double Helix structure of DNA allows it to replicate easily due to the weak hydrogen bonds that unzip quickly. The structure allows allot of information to be stored in small space as the double helix curves.
The DNA structure shows important information on how DNA replication occurs. The pairing pattern of the nitrogen bases is the key to understanding how it occurs. The four nitrogen bases are adenine, thymine, guanine, and cytosine. Only adenine and thymine pair together and only guanine and cytosine pair together.
KEY FACT In 1953, James Watson and Francis Crick put forward their hypothesis that DNA had a double helix structure. Their first attempt to identify the structure of DNA was not successful, however, in 1953 they put forward their hypothesis that DNA had a double helix structure.
In prokaryotes: DNA gyrase - a topoisomerase II protein that introduces negative supercoils in the DNA to reduce torsional stressDNA helicase - breaks the hydrogen bonds between nucleotides and unzips the DNA double helixSingle stranded binding proteins - stabilize DNA be keeping the DNA strands from reannealingDNA Polymerase III - polymerizes nucleotides forming a new DNA strandLoading clamp - loads the DNA strand into pol IIIDNA Primase - lays down an RNA primer on the lagging strandDNA Polymerase I - replaces RNA primer with DNADNA Ligase - ligates DNA strand together on the lagging strandIn eukaryotes:DNA Pol III is replaced by DNA Pol DeltaPol I is replaced by Pol AlphaRPA - replication protein A replaces the SSBsRFC - replication factor C replaces DNA loading clampPCNA replaces the beta subunit
Easily Explained thusly: When the key is in the lock the Enzyme has one Structure, and when the key is not in the lock the Enzyme has another Structure. Note that the presence of a key may either activate or deactivate an Enzyme, depending upon the conditions.
DNA polymerase checks DNA for errors.DNA polymerase checks DNA for errors by breaking the hydrogen bonds between the paired nitrogen bases in the DNA molecule. This causes the molecule to separate into two individual strands.
DNA (deoxyribonucleic acid) is composed of two types of molecules: deoxyribose sugars and phosphate groups. These molecules form the backbone of the DNA strand, with the deoxyribose sugars and phosphate groups alternating to create a stable structure.
Alfred Delbruck was a German biophysicist who made significant contributions to the field of molecular biology, particularly in the study of bacteriophages. He is known for his work on the structure and replication of viral DNA. Delbruck also played a key role in the development of the "phage group," a collaborative research effort that laid the foundation for the field of molecular biology.