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In prokaryotes: DNA gyrase - a topoisomerase II protein that introduces negative supercoils in the DNA to reduce torsional stress
DNA helicase - breaks the hydrogen bonds between nucleotides and unzips the DNA double helix
Single stranded binding proteins - stabilize DNA be keeping the DNA strands from reannealing
DNA Polymerase III - polymerizes nucleotides forming a new DNA strand
Loading clamp - loads the DNA strand into pol III
DNA Primase - lays down an RNA primer on the lagging strand
DNA Polymerase I - replaces RNA primer with DNA
DNA Ligase - ligates DNA strand together on the lagging strand


In eukaryotes:
DNA Pol III is replaced by DNA Pol Delta
Pol I is replaced by Pol Alpha
RPA - replication protein A replaces the SSBs
RFC - replication factor C replaces DNA loading clamp
PCNA replaces the beta subunit

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