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You need to have the vet check them. One possible cause is ringworm (it's a fungus, not an actual worm). If they have ringworm, it can be treated with antifungal ointment. Make sure your vet advises you which ointment is safe for such young kittens.

Also, make sure they do not have fleas. A serious flea infestation can weaken kittens, making them anemic, and possibly leading to hair loss. If it's really bad it could even lead to their death through severe anemia. At three weeks, they should not be exposed to chemical flea products. You can bathe them gently in warm water and baby shampoo (make sure you rinse them well so they won't lick the shampoo off their fur) and use a flea comb.

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Q: Your 3 week old kittens are getting bald spots what is this and what can you use to get rid of it without harming the kittens?
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