Grapefruit has a lot of Vitamin C plus some enzymes that seem to
speed up things . (For a while back in the 60's- grapefruit was
thought to be a fat burner. )
Some antibiotics i.e. Erythromycin and other drugs which are in
this class (the Not Pencillins) do not mix well at all, especially
with Garpefruit. So those of you who take Erythromycin because of
your pencillin allergies should be careful; especially when taking
megadoses of Vitamin C or eating grapefruit.
The end result is your liver gets a big buildup of drugs it
cannot handle - you are actually poisoning your self because the
drugs are not working properly.
Here is the science: Erythromycin competes - It does the exact
same thing as Vitamin C: it inhibits the cytochrome P450 system,
particularly the CYP3A4 isozyme, which can cause it to affect the
metabolism of many different drugs, not just Vitamin C.
I am not the pharmacist- just a smart nutritionist student who
knows biochemistry. When I graduate I will sign this. In the
meantime you are provided with the following
quoted directly from a professional source D.McAuley,
with references GlobalRPH.com
His site is a great study guide as well. Just always give him
credit because he has copyrighted the site.
" Grapefruit juice is a potent inhibitor of the intestinal
cytochrome P-450 3A4 system (specifically: CYP3A4 - mediated drug
metabolism) which is responsible for the first-pass metabolism of
many medications. This interaction can lead to increases in
bioavailability and corresponding increases in serum drug
levels.
In many cases, the increased serum drug levels can produce some
readily observable symptoms. Here are a few examples of adverse
effects that are possible when the following medications are taken
concurrently with grapefruit.
(1) Excessive sedation: benzodiazepines.
(2) Increased risk of rhabdomyolyis: HMG-CoA reductase
inhibitors (statins)-- there are some exceptions.
(3) Symptomatic hypotension: dihydropyridine calcium antagonists
(some exceptions exist). (4) QT interval prolongation: astemizole,
cisapride, pimozide, terfenadine. "Drug interactions may be most
apparent when patients are stabilized on the affected drug and the
CYP3A4 inhibitor is then added to the regimen." 5
CONVERSELY THE VITAMIN C THAT IS FACILITATED BY THE ENZYMES IN
GRAPEFRUIT IS NOT ALL BAD>>>> the problem is that the
drugs you take work on the same enzyme activation sites or pathways
and only one thing can work well at a time or in the case of some
drugs like the heart medicines the heartbeat is sped up or slowed
down which is NOT what the doctor ordered when he put you on the
medication.
There may be some pharmacological advantages to this
interaction. If the interaction is taken into account during the
initialization of drug therapy it is possible to decrease drug
dosages. This concept can be applied to cyclosporine therapy. If a
patient regularly consumes grapefruit, lower dosages of
cyclosporine will be required, which will lead to lower drug
costs.
IN CONCLUSION
Grapefruit juice is not the only inhibitor of this enzyme
system. Other drugs which have a similar effect include:
clarithromycin (Biaxin ®), erythromycin (E-Mycin ®, others),
itraconazole (Sporonox ®), ketoconazole (Nizoril ®), nefazodone
(Serzone ®), and ritonavir (Norvir ®). "
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© D.McAuley, GlobalRPH.com 2001